Cold Sores

1. Pringle, C. R. Merck Manual. Merk Manual (Merck Sharp & Dohme Corp., 2018). doi:10.1001/ archsurg.1972.04180110125043
2. James, C., et al. Herpes simplex virus: Global infection prevalence and incidence estimates, 2016. Bull. World Health Organ. 98, 315–329 (2020).
3. Usatine, R. P. & Tinitigan, R. Nongenital herpes simplex virus. Am. Fam. Physician 82, 1075–1082 (2010).
4. Saleh D., Yarrarapu SNS., Sharma S. Herpes Simplex Type 1. StatPearls Publishing (2020) doi: 10.5772/21902.
5. Padgett, D. A., Sheridan, J. F., Dorne, J., Berntson, G. G., Candelora, J. & Glaser, R. Social stress and the reactivation of latent herpes simplex virus type 1. Proc. Natl. Acad. Sci. U. S. A. 95, 7231–7235 (1998).
6. Schmidt, D. D., Zyzanski, S., Ellner, J., Kumar, M. L. & Arno, J. Stress as a precipitating factor in subjects with recurrent herpes labialis. J. Fam. Pract. 20, 359–366 (1985).
7. Mayo Clinic. Cold sore [online] [cited 2018 November 28.]; Available from URL: https://www.mayoclinic.org/diseases-conditions/cold-sore/symptoms-causes/syc-20371017
8. Acitop approved Professional Information, June 2003.
9. InformedHealth.Org (Internet). How effective are creams and tablets for the treatment of cold sores. Institute for Quality and Efficiency in Health Care (IQWiG) 6-8 https://www.ncbi.nlm.nih.gov/books/NBK525789/ (2006).
10. Based on internal analysis by iNova Pharmaceuticals (Pty) Ltd using data from the following source: IQVIA TPM MAT December 2024 ACT4 D6D1 Topical Antivirals. Brands are measured in Units, reflecting estimates of real-world activity. Copyright IQVIA.

ACITOP cream. Reg. No. 32/20.2.8/0719.  Reg. No. 06/20.2.8/0099 (Namibia). Each gram of cream contains 50 mg of Acyclovir (5,0 % w/w Acyclovir).  Marketed by: iNova Pharmaceuticals (Pty) Limited. Co. Reg. No. 1952/001640/07, 15E Riley Road, Bedfordview. Tel. No. 011 087 0000. www.inovapharma.co.za. For full prescribing information, refer to the approved Professional Information. For more information, speak to your healthcare professional.

IN5054/25

Applicant: CIPLA MEDPRO (PTY) LTD Co. Reg. No. 1995/004 182/07. Building 9. Parc du Cap, Mispel Street, Bellville, 7530, RSA. Website: www.cipla.co.za Customer Care: 080 222 6662